Cialis: the third pill against male impotence

Tadalafil is a medication prescribed and used for the treatment of erectile dysfunction, or as known sexual impotence. It was developed by the biotechnology company ICOS and marketed by the Eli Lilly Pharmaceutical Laboratory under the name Cialis. It has been considered “the third pill against male impotence” after Viagra, in first place and Levitra , in second place. The ill you should be taken in 20 to 30 minutes before planned sexual activity. Due to its effects can last up to 36 hours, it’s often called “the weekend pill”.

The physiological process of erection involves the release of nitric oxide (NO) to the cavernous body of the penis. Nitric oxide binds to receptors of the enzyme guanylate cyclase, which causes an increase in the levels of cyclic guanosine monophosphate (cGMP). CGMP promotes a relaxation of the muscular wall of the blood vessels of the penis, increasing blood flow and enabling erection.Tadalafil is a potent selective inhibitor of PDE5 (phosphodiesterase type 5), an enzyme found primarily in the walls of the arteries of the penis and lungs and responsible for the degradation of cGMP in the corpus cavernosum. The chemical structure of tadalafil has some similarity to the structure of cGMP, and competes with it for the binding to PDE5. This results in an increase in cGMP levels and better erections. Tadalafil is not able to produce erections by itself, without the presence of sexual stimuli, because without these there is no activation of the nitric oxide / cGMP system. Sildenafil (Viagra) and vardenafil (Levitra) act similarly. Tadalafil is being studied as a possible treatment for pulmonary arterial hypertension, thanks to its effect on cGMP. Tadalafil is expected to allow the opening of pulmonary blood vessels, reducing pressure and resistance in the pulmonary arteries, and decreasing the workload of the right ventricle of the heart.

Tadalafil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. The less common effects are:Arm, back, or jaw pain; blurred vision; chest pain or discomfort; chest tightness or heaviness; chills; cold sweats; confusion; dizziness; fainting; faintness or lightheadedness when getting up suddenly from a lying or sitting position; fast or irregular heartbeat; headache; hearing loss; nausea; nervousness; pain or discomfort in the arms jaw, back, or neck; pounding in the ears; shortness of breath; slow or fast heartbeat; sweating; unusual tiredness or weakness; vomiting. A rare side effect could be painful or prolonged erection of the penis.

Cialis over the internet

Cialis can be purchased on the internet in various websites without prescription. In the “edonlinestores.net” website, for example, the drug can be purchased in packages of 10 mg, 20 mg, 40 mg, 60 mg and 80 mg, up to 360 pills per package. Air mail delivery services are free of charge for order over 2.70 and trackable services cost .91 Australian dollars. This includes 10% discount for the next order. The product is Generic Cialis, which are affordable prices. The is no difference in activity between Generic Cialis and original Cialis and the are considerably cheaper.

John Rogers

I have been working in General Practice since 2006.